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KMID : 0383820080640050362
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Tuberculosis and Respiratory Diseases
2008 Volume.64 No. 5 p.362 ~ p.368
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The Clinical and Histopathologic Features according to Loss of LKB1 Protein Expression on Primary Lung Cancer
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Hwang Jong-Yun
Jo Hyang-Jeong
Lee Kang-Kyoo
Shim Hyeok
Song Jung-Sub
Shin Jeong-Hyun
Shin Seong-Nam
Park Seong-Hoon
Hong Kyeong-Man
Park Jung-Hyun
Jeong Jong-Hoon
Kim Hui-Jung
Kim Hak-Ryul
Yang Sei-Hoon
Jeong Eun-Taik
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Abstract
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Background: LKB1(STK11) is a serine/threonine kinase that functions as a tumor growth suppressor.
The functions of LKB1 in lung cancer are not completely understood. This study evaluated the relationship between LKB1 protein expression and the clinicopathological features in lung cancer tissues.
Methods: The expression of LKB1 was studied in paraffin-embedded tumor blocks, which were obtained from 77
patients who had undergone surgery at Wonkwang University Hospital. The expression of the LKB1 protein was considered positive if the staining intensity in the tumor tissue adjacent to the normal airway epithelium was ＞30%.
Results: The LKB1 expression was positive in 31 (40%) of samples. Loss of LKB1 expression was significantly
associated with being male, smoking history, and squamous cell carcinoma. In the peripheral sites, the loss of LKB1 expression was strongly associated with a smoking history. A loss of LKB1 expression was more frequently associated with progression according to TNM staging, particularly more than T2, N progression.
Conclusion: There was a significant relationship between the loss of the LKB1 protein and gender, smoking history, and histological type in primary lung cancer. Although LKB1 expression was not found to be a significant prognostic factor, further studies with a larger cohort of patient’s lung cancer tissue samples will be needed to confirm
this. (Tuberc Respir Dis 2008;64:362-368)
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KEYWORD
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LKB1, Gender, Smoking, Lung cancer
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